New technology is being introduced by ISA Pharmaceuticals to test cancers

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Clinical trials for Amplivant, an adjuvant technology that boosts the immune response to cancer therapy, have begun in the United States. A multicenter clinical trial evaluating the Moditop vaccine, Modi-1, and ISA Pharmaceuticals’ novel technology is currently underway.

Patients with triple-negative breast cancer, ovarian cancer, head and neck cancer, and renal cancer will be given Amplivant adjuvant therapy as part of the first-in-human clinical trial for Modi-1 treatment.

Adjuvants are crucial components of vaccines that increase efficacy, but there is a lack of new, innovative, and effective adjuvants in development to add to a limited arsenal, explained Professor Kees Melief, chief scientific officer, ISA Pharmaceuticals.

As such, this is a significant accomplishment that demonstrates the value of our working relationship with Scancell. The trial provides an additional opportunity to demonstrate the potent adjuvant properties that Amplivant confers on therapeutic vaccines in order to potentially benefit patients with a wide range of solid tumors, “added Melief.

The primary study is an open-label clinical trial designed to evaluate Modi-1’s safety and immunogenicity.

Scancell CEO Lindy Durrant said, “This is the first time we have taken a product from our Moditope platform into cancer patients and it is a major step forward for Scancell and our collaboration with ISA Pharmaceuticals.” “Based on the dramatic regression of large tumors in our preclinical models, we are very excited about the potential of Modi-1.”

Head and neck cancer patients in neoadjuvant treatment will be studied to see if Modi-1 has an effect on enhancing tumor cell infiltration. The term “neoadjuvant” refers to a type of treatment used to help shrink a tumor before a more serious one is administered.

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Zaid Quraishi
My name is Zaid Quraishi. I pride myself on being a meticulous and organized individual who has done his Bachelors in Medical Technology and currently pursuing my Master's in the same course from Sher-e-Kashmir Institute of Medical Sciences. I belong to the beautiful valley of Kashmir, and my hometown is Srinagar. I am the elder sibling of my younger brother. As far as my strengths are concerned, I am effectively communicative, optimistic, reliable, a team player, and time-efficient. My weaknesses are that I am an honest person and I tend to be blunt, and sometimes, I like to work alone. I am passionate about content writing, online gaming, and learning new things, especially languages (currently German). I have written two papers for my University degree, which helped me immensely in learning how to write effectively. I am confident in my writing skills, and I can effectively pour my thoughts out in writing and express myself so that the reader relates to it and is intrigued by the content. I love to play with my pet cat, and she is a darling to me. The thing that I dislike the most is being distracted when you are in the zone. Currently, I am a content writer in a dynamic work environment at Shouzy, ready to improve readers' satisfaction and increase retention levels.

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